1-Methyl-3-pyrrolidinol, (-)- → HCID 118036710, compound

HRID 1777899Notes

Reaction equation

HRID 1777899 reaction equation
[NH2:1][C:2]1[CH:9]=[C:8](F)[C:5]([C:6]#[N:7])=[CH:4][N:3]=1.[CH3:11][N:12]1[CH2:16][CH2:15][C@@H:14]([OH:17])[CH2:13]1>>[NH2:1][C:2]1[CH:9]=[C:8]([O:17][C@@H:14]2[CH2:15][CH2:16][N:12]([CH3:11])[CH2:13]2)[C:5]([C:6]#[N:7])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 69513321-Methyl-3-pyrrolidinol, (-)-HCID 1180369016-Amino-4-fluoronicotinonitrile

Product 1

HCID 118036710HCID 118036710, compound

Procedure

From intermediate 21 and (R)-1-methylpyrrolidin-3-ol, reacted in an analogous manner to the preparation of intermediate 47. (UPLC-MS 3) tR 0.28 min; ESI-MS 219.2 [M+H]+.

Sources & evidence

ORD record
ord-eeffa67c558c4584a735195e97f0651c
Source dataset
uspto-grants-2016_02
Patent number
US09266883B2

Reaction notes

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