(1-Methyl-3-piperidyl)methanol → HCID 118036708, compound

HRID 1777900Notes

Reaction equation

HRID 1777900 reaction equation
[NH2:1][C:2]1[CH:9]=[C:8](F)[C:5]([C:6]#[N:7])=[CH:4][N:3]=1.[CH3:11][N:12]1[CH2:17][CH2:16][CH2:15][CH:14]([CH2:18][OH:19])[CH2:13]1>>[NH2:1][C:2]1[CH:9]=[C:8]([O:19][CH2:18][CH:14]2[CH2:15][CH2:16][CH2:17][N:12]([CH3:11])[CH2:13]2)[C:5]([C:6]#[N:7])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 97998(1-Methyl-3-piperidyl)methanolHCID 1180369016-Amino-4-fluoronicotinonitrile

Product 1

HCID 118036708HCID 118036708, compound

Procedure

From intermediate 21 and racemic (1-methylpiperidin-3-yl)methanol, reacted in an analogous manner to the preparation of intermediate 47. (UPLC-MS 3) tR 0.33 min; ESI-MS 247.2 [M+H]+.

Sources & evidence

ORD record
ord-25b5b69dd97d4b29ba638215ca243bf8
Source dataset
uspto-grants-2016_02
Patent number
US09266883B2

Reaction notes

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