Oxolan-3-amine → HCID 118036164, compound

HRID 1777905Notes

Reaction equation

HRID 1777905 reaction equation
[NH2:1][C:2]1[CH:9]=[C:8](F)[C:5]([C:6]#[N:7])=[CH:4][N:3]=1.[O:11]1[CH2:15][CH2:14][CH:13]([NH2:16])[CH2:12]1>>[NH2:1][C:2]1[CH:9]=[C:8]([NH:16][CH:13]2[CH2:14][CH2:15][O:11][CH2:12]2)[C:5]([C:6]#[N:7])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 3365553Oxolan-3-amineHCID 1180369016-Amino-4-fluoronicotinonitrile

Product 1

HCID 118036164HCID 118036164, compound

Procedure

From intermediate 21 and racemic tetrahydrofuran-3-amine, reacted in an analogous manner to the preparation of intermediate 49. (UPLC-MS 3) tR 0.32 min; ESI-MS 205.1 [M+H]+.

Sources & evidence

ORD record
ord-582211a444c34f4283e90f6f8c59e2b7
Source dataset
uspto-grants-2016_02
Patent number
US09266883B2

Reaction notes

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