2-Methoxypropan-1-amine → HCID 118036603, compound

HRID 1777906Notes

Reaction equation

HRID 1777906 reaction equation
[NH2:1][C:2]1[CH:9]=[C:8](F)[C:5]([C:6]#[N:7])=[CH:4][N:3]=1.[CH3:11][O:12][CH:13]([CH3:16])[CH2:14][NH2:15]>>[NH2:1][C:2]1[CH:9]=[C:8]([NH:15][CH2:14][CH:13]([O:12][CH3:11])[CH3:16])[C:5]([C:6]#[N:7])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 126097192-Methoxypropan-1-amineHCID 1180369016-Amino-4-fluoronicotinonitrile

Product 1

HCID 118036603HCID 118036603, compound

Procedure

From intermediate 21 and racemic 2-methoxypropan-1-amine, reacted in an analogous manner to the preparation of intermediate 49. (UPLC-MS 3) tR 0.39 min; ESI-MS 207.1 [M+H]+.

Sources & evidence

ORD record
ord-f11a955e66c0440ea9b9db25685b9099
Source dataset
uspto-grants-2016_02
Patent number
US09266883B2

Reaction notes

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