反应详情

温度

60 °C

A mixture of racemic 2-dimethylaminomethylmorpholine (670 mg, 4.65 mmol), 6-amino-4-fluoronicotinonitrile (intermediate 21, 637 mg, 4.65 mmol) and triethylamine (2.59 ml, 18.6 mmol) was heated at 60° C. in a septum sealed reaction vessel under argon for 10 h. The reaction mixture was evaporated, partitioned between aq. hydrochloric acid (2 M) and DCM (2×), the aqueous layer basified with aqueous NaHCO3, extracted a further 10× with DCM containing 10% MeOH, the combined DCM layers from the basic extraction, dried over Na2SO4 and evaporated. The residue was applied to a 24 g RediSep® silica column as a DCM solution and purified by normal phase chromatography, eluting with a gradient from DCM to 20% MeOH in DCM. Product containing fractions were combined and evaporated to give the title compound as a beige foam. (UPLC-MS 6) tR 0.28; ESI-MS 262.2 [M+H]+.

1. customsealed
2. customreaction vessel under argon for 10 h
3. customThe reaction mixture was evaporated
4. custompartitioned between aq. hydrochloric acid (2 M) and DCM (2×)
5. extractionextracted a further 10× with DCM containing 10% MeOH
6. extractionthe combined DCM layers from the basic extraction
7. dry with materialdried over Na2SO4
8. customevaporated
9. custompurified by normal phase chromatography
10. washeluting with a gradient from DCM to 20% MeOH in DCM
11. additionProduct containing fractions
12. customevaporated