2,2,2-Trifluoroethanol → HCID 118036602, compound

Participants

Reaction Steps

A solution of KHMDS in THF (1 M, 16.1 ml, 16.04 mmol) was added drop wise to a solution of 2,2,2-trifluoroethanol (0.53 ml, 7.29 mmol) in THF (40 ml) at room temperature. After 2 min a solution of 6-amino-4-fluoronicotinonitrile (intermediate 21, 1.0 g, 7.29 mmol) in THF (10 ml) was added and the reaction mixture stirred for 2 h at room temperature. The reaction mixture was partitioned between saturated aqueous NH4Cl and EtOAc, extracted with EtOAc (2×), the combined organic layers were dried over Na2SO4 and evaporated. The residue was triturated with Et2O and heptane to give the title compound. (UPLC-MS 7) tR 0.70; ESI-MS 218.1 [M+H]+.

Provenance & Evidence