2-Fluoroethanol → HCID 118036820, compound

HRID 1777949Notes

Reaction equation

[NH2:1][C:2]1[CH:9]=[C:8](F)[C:5]([C:6]#[N:7])=[CH:4][N:3]=1.[F:11][CH2:12][CH2:13][OH:14]>>[NH2:1][C:2]1[CH:9]=[C:8]([O:14][CH2:13][CH2:12][F:11])[C:5]([C:6]#[N:7])=[CH:4][N:3]=1

Participants

Reactant 2

HCID 97372-Fluoroethanol

HCID 1180369016-Amino-4-fluoronicotinonitrile

Product 1

HCID 118036820HCID 118036820, compound

Procedure

From intermediate 21 and 2-fluoroethanol, reacted in an analogous manner to the preparation of intermediate 89. (UPLC-MS 6) tR 0.50; ESI-MS 182.0 [M+H]+.

Sources & evidence

ORD record: ord-6f11e5b7092440fe96cf98ab8e9095d5
Source dataset: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09266883B2

Reaction notes

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