2-(Tert-butoxy)ethanamine → 6-Amino-4-((2-(tert-butoxy)ethyl)amino)nicotinonitrile

HRID 1777960Notes

Reaction equation

HRID 1777960 reaction equation
[NH2:1][C:2]1[CH:9]=[C:8](F)[C:5]([C:6]#[N:7])=[CH:4][N:3]=1.[C:11]([O:15][CH2:16][CH2:17][NH2:18])([CH3:14])([CH3:13])[CH3:12]>>[NH2:1][C:2]1[CH:9]=[C:8]([NH:18][CH2:17][CH2:16][O:15][C:11]([CH3:14])([CH3:13])[CH3:12])[C:5]([C:6]#[N:7])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 219146142-(Tert-butoxy)ethanamineHCID 1180369016-Amino-4-fluoronicotinonitrile

Product 1

HCID 1180369686-Amino-4-((2-(tert-butoxy)ethyl)amino)nicotinonitrile

Procedure

From intermediate 21 and 2-(tert-butoxy)ethanamine, reacted in an analogous manner to the preparation of intermediate 102. (UPLC-MS 3) Rt=0.58 min; MS m/z [M+H]+ 235.

Sources & evidence

ORD record
ord-fab6132a493c46b7acac8c90fca48159
Source dataset
uspto-grants-2016_02
Patent number
US09266883B2

Reaction notes

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