2-Propanamine, 1-methoxy-, (2S)- → HCID 118036484, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (S)-1-methoxy-2-propylamine (5.91 g, 65.6 mmol), 6-amino-4-fluoronicotinonitrile (intermediate 21, 3.0 g, 21.88 mmol) and diidopropylethylamine (11.52 ml, 65.6 mmol) in DMA (50 ml) was heated at 60° C. in a septum sealed reaction vessel for 48 h. The reaction mixture partitioned between DCM and aqueous NH4Cl, extracted with DCM (3×), the combined organic extracts were dried over Na2SO4 and evaporated to give the title compound as a pale yellow oil. (UPLC-MS 7) tR 0.40; ESI-MS 207.1 [M+H]+.

Provenance & Evidence