(+)-2-Amino-1-methoxypropane → HCID 118036471, compound

HRID 1777968Notes

Reaction equation

HRID 1777968 reaction equation
[NH2:1][C:2]1[CH:9]=[C:8](F)[C:5]([C:6]#[N:7])=[CH:4][N:3]=1.[CH3:11][O:12][CH2:13][C@H:14]([NH2:16])[CH3:15]>>[NH2:1][C:2]1[CH:9]=[C:8]([NH:16][C@H:14]([CH3:15])[CH2:13][O:12][CH3:11])[C:5]([C:6]#[N:7])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 10313069(+)-2-Amino-1-methoxypropaneHCID 1180369016-Amino-4-fluoronicotinonitrile

Product 1

HCID 118036471HCID 118036471, compound

Procedure

From intermediate 21 and (R)-1-methoxy-2-propylamine, reacted in an analogous manner to the preparation of intermediate 112. (UPLC-MS 7) tR 0.42; ESI-MS 207.1 [M+H]+.

Sources & evidence

ORD record
ord-e284d316084c4c09a8c3243e06b90da9
Source dataset
uspto-grants-2016_02
Patent number
US09266883B2

Reaction notes

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