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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1777984Generated: November 2, 2026

2-(Oxan-2-yloxy)ethan-1-ol → (racemic) 6-amino-4-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)nicotinonitrile

https://huagongshe.com/reaction/1777984

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Oxan-2-yloxy)ethan-1-olHCID 4166833—
Reactant6-Amino-4-fluoronicotinonitrileHCID 118036901—
Reactant(R)-6-amino-4-((1-methoxypropan-2-yl)oxy)nicotinonitrileHCID 118036909—
Product(racemic) 6-amino-4-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)nicotinonitrileHCID 118036947—

Reaction Steps

From intermediate 21 and (racemic) 2-((tetrahydro-2H-pyran-2-yl)oxy)ethanol, reacted in an analogous manner to the preparation of intermediate 146. (UPLC-MS 7) tR 0.70; ESI-MS 264.1 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09266883B2
Source datasetuspto-grants-2016_02
ORD IDord-8ecd740b81894d20b86536c9cc32b453
Source noteuspto-grants-2016_02