HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1778023Generated: November 2, 2026
Trifluoroacetic acid → 6-bromo-1-isopropyl-1H-imidazo[4,5-c]pyridine
https://huagongshe.com/reaction/1778023
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | 6-bromo-N4-isopropylpyridine-3,4-diamine | HCID 90176649 | — |
| Product | 6-bromo-1-isopropyl-1H-imidazo[4,5-c]pyridine | HCID 90177760 | — |
Reaction Steps
A mixture of 6-bromo-N4-isopropylpyridine-3,4-diamine (intermediate 257, 1.2 g, 5.22 mmol), triethylorthoformate (26.6 ml, 156 mmol) and TFA (0.24 ml, 3.12 mmol) was heated at 125° C. for 3.5 h and then concentrated. The residue was diluted with sat. aq. NaHCO3 and extracted with
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09266883B2 |
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| Source dataset | uspto-grants-2016_02 |
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| ORD ID | ord-724fcb968a834c679e5bafe06f0355d6 |
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| Source note | uspto-grants-2016_02 |
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