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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1778028Generated: November 1, 2026

4-(Hydroxymethyl)piperidin-2-one → (Racemic) 6-amino-4-((2-oxopiperidin-4-yl)methoxy)nicotinonitrile

https://huagongshe.com/reaction/1778028

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Hydroxymethyl)piperidin-2-oneHCID 21840017—
Reactant6-Amino-4-(2-methoxyethoxy)nicotinonitrileHCID 118036841—
Product(Racemic) 6-amino-4-((2-oxopiperidin-4-yl)methoxy)nicotinonitrileHCID 118036317—

Reaction Steps

From (racemic) 4-(hydroxymethyl)piperidin-2-one, synthesized in an analogous manner to intermediate 20, the title compound was obtained as a beige solid. (UPLC-MS 6) tR 0.42; ESI-MS 247.2 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09266883B2
Source datasetuspto-grants-2016_02
ORD IDord-e7ed013beb044f0d90f218bdca047621
Source noteuspto-grants-2016_02