HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-6-bromo-7-(dimethoxymethyl)-2-methyl-1,2,3,4-tetrahydro-1,8-naphthyridine → (S)-1-((2-(dimethoxymethyl)-7-methyl-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)methyl)-4-methylpiperazin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-6-bromo-7-(dimethoxymethyl)-2-methyl-1,2,3,4-tetrahydro-1,8-naphthyridine | HCID 118036532 | — |
| Reactant | 1-((2-(Dimethoxymethyl)-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)methyl)-4-methylpiperazin-2-one | HCID 118036658 | — |
| Product | (S)-1-((2-(dimethoxymethyl)-7-methyl-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)methyl)-4-methylpiperazin-2-one | HCID 118036828 | — |
Reaction Steps
From (S)-6-bromo-7-(dimethoxymethyl)-2-methyl-1,2,3,4-tetrahydro-1,8-naphthyridine (intermediate 264 (enantiomer 1)), synthesized in an analogous manner to intermediate 81, the title compound was obtained as a brown solid. (UPLC-MS 6) tR 0.39; ESI-MS 349.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09266883B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-f405fa7ef9be42a1b5e4654e4e14bb03 |
| Source note | uspto-grants-2016_02 |