HCID 118036781, compound → HCID 118036623, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-(1,3-dioxolan-2-yl)-1H-pyrrolo[2,3-b]pyridine (intermediate 292, 0.283 g, 1.443 mmol), and Raney nickel (0.140 g) in EtOH (30 ml) was stirred under a hydrogen atmosphere (5 bar) at 95° C. in an autoclave reactor. Additional Raney nickel (0.140 g) was added after 22 h. After 27 h, the reaction mixture was cooled to room temperature, poured onto a glass fiber filter, washed through with additional EtOH and concentrated to give the crude title compound as a brown oil. This was used withoug purification in the next step. (UPLC-MS 6) tR 0.38; ESI-MS 193.1 [M+H]+.

Provenance & Evidence