Hydrochloric Acid → HCID 118036691, compound

Participants

Reaction Steps

Hydrochloric acid (4 M, 10.9 ml) was added to a solution of N-(4-((2-(tert-butoxy)ethyl)amino)-5-cyanopyridin-2-yl)-7-(dimethoxymethyl)-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide (intermediate 120C, 1.3 g, 2.19 mmol) in THF (20 ml) at room temperature. After stirring for 1 h at room temperature, sat. aq. NaHCO3 was added and the mixture extracted with DCM. The combined organic layers were washed with brine, dried over MgSO4 and evaporated. The residue was triturated with Et2O to give the title compound as a white solid.

Provenance & Evidence