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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1778107Generated: November 3, 2026

N-(5-cyanopyridin-2-yl)-2-(dimethoxymethyl)-7,8-dihydro-5H-pyrido[2,3-b]azepine-9(6H)-carboxamide → N-(5-cyano-4-(2-methoxyethoxy)pyridin-2-yl)-2-formyl-7,8-dihydro-5H-pyrido[2,3-b]azepine-9(6H)-carboxamide

https://huagongshe.com/reaction/1778107

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-(5-cyanopyridin-2-yl)-2-(dimethoxymethyl)-7,8-dihydro-5H-pyrido[2,3-b]azepine-9(6H)-carboxamideHCID 118037151—
ReactantPhenyl (5-cyano-4-(2-methoxyethoxy)pyridin-2-yl)carbamateHCID 125470569—
ProductN-(5-cyano-4-(2-methoxyethoxy)pyridin-2-yl)-2-formyl-7,8-dihydro-5H-pyrido[2,3-b]azepine-9(6H)-carboxamideHCID 118036287—

Reaction Steps

From intermediates 108 and 237, coupled and deprotected in an analogous manner to intermediate 236 and Example 201. The title compound was obtained as a white solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09266883B2
Source datasetuspto-grants-2016_02
ORD IDord-6c806f6e36b84c3880bf832011c0cc36
Source noteuspto-grants-2016_02