HRID1778112

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID118036951

未命名化合物

结构：COCCNc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)CC4=O)c(C(OC)OC)nc32)ncc1C#N

HCID118037008

未命名化合物

PRODUCTS

生成物

结构：COCCNc1cc(NC(=O)N2c3nc(C=O)c(CN4CCN(C)CC4=O)cc3CC[C@@H]2C)ncc1C#N

HCID118037040

未命名化合物

PROCEDURE

实验过程

From intermediates 75 and 268, coupled and deprotected in an analogous manner to intermediate 80 and Example 201. The title compound was obtained as a white solid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-68e518736d3d4391b913dc06c297ec8a
来源数据集: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09266883B2
来源说明: uspto-grants-2016_02

反应 SMILES

N[C:2]1C=C(NCCOC)C(C#N)=CN=1.[C:15]([C:17]1[C:18]([NH:50][CH2:51][CH2:52][O:53][CH3:54])=[CH:19][C:20]([NH:23][C:24]([N:26]2[C:35]3[C:30](=[CH:31][C:32]([CH2:41][N:42]4[CH2:47][CH2:46][N:45]([CH3:48])[CH2:44][C:43]4=[O:49])=[C:33]([CH:36](OC)[O:37]C)[N:34]=3)[CH2:29][CH2:28][CH2:27]2)=[O:25])=[N:21][CH:22]=1)#[N:16]>>[C:15]([C:17]1[C:18]([NH:50][CH2:51][CH2:52][O:53][CH3:54])=[CH:19][C:20]([NH:23][C:24]([N:26]2[C:35]3[C:30](=[CH:31][C:32]([CH2:41][N:42]4[CH2:47][CH2:46][N:45]([CH3:48])[CH2:44][C:43]4=[O:49])=[C:33]([CH:36]=[O:37])[N:34]=3)[CH2:29][CH2:28][C@@H:27]2[CH3:2])=[O:25])=[N:21][CH:22]=1)#[N:16]