Hydrochloric Acid → HCID 118036257, compound

Participants

Reaction Steps

Concentrated hydrochloric acid (0.28 ml) was added to a solution of N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-(dimethoxymethyl)-6-(tetrahydro-2H-pyran-4-yl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide (intermediate 310, 640 mg, 0.689 mmol) in THF (6 ml) and water (2 ml) at room temperature. After stirring for 4 h at room temperature saturated aqueous NaHCO3 was added, the mixture extracted with DCM, the organic layers dried over MgSO4 and evaporated. The residue was triturated with EtOAc and then filtered to give the title compound as a white solid.

Provenance & Evidence