Hydrochloric Acid → HCID 118037102, compound

Participants

Reaction Steps

A mixture of tert-butyl 4-(8-((5-cyano-4-isopropoxypyridin-2-yl)carbamoyl)-2-(dimethoxymethyl)-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)piperidine-1-carboxylate (intermediate 338, 55 mg) and 4N HCl in dioxane (0.35 ml) was stirred at room temperature. After 3 h, additional 4N HCl in dioxane (0.15 ml) was added. After 5 h, the reaction mixture was diluted with sat. aq. NaHCO3 and extracted with DCM (3×). The combined organic phases were dried over Na2SO4 and evaporated. The residue was triturated with Et2O to give the title compound as a white solid.

Provenance & Evidence