4-Chloro-3-(trifluoromethyl)benzoic acid → HCID 118130086, compound

HRID 1778129Notes

Reaction equation

HRID 1778129 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[CH:11]=[N:12][CH:13]=[C:14]([CH:19]=2)[C:15]([O:17][CH3:18])=[O:16])[CH:5]=[CH:6][CH:7]=1.[Cl:20][C:21]1[CH:29]=[CH:28][C:24]([C:25](O)=[O:26])=[CH:23][C:22]=1[C:30]([F:33])([F:32])[F:31]>>[Cl:20][C:21]1[CH:29]=[CH:28][C:24]([C:25]([NH:1][C:2]2[CH:3]=[C:4]([C:8]#[C:9][C:10]3[CH:11]=[N:12][CH:13]=[C:14]([CH:19]=3)[C:15]([O:17][CH3:18])=[O:16])[CH:5]=[CH:6][CH:7]=2)=[O:26])=[CH:23][C:22]=1[C:30]([F:31])([F:32])[F:33]

Participants

3

Reactant 2

HCID 27738574-Chloro-3-(trifluoromethyl)benzoic acidHCID 118130124HCID 118130124, compound

Product 1

HCID 118130086HCID 118130086, compound

Procedure

In a manner similar to that described in Example 1, methyl 5-((3-aminophenyl)ethynyl)nicotinate and 4-chloro-3-(trifluoromethyl)benzoic acid are converted to the title compound.

Sources & evidence

ORD record
ord-e05d4cd3ad1c4aa5ab34e1a194297ae0
Source dataset
uspto-grants-2016_02
Patent number
US09266869B2

Reaction notes

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