3-(Trifluoromethyl)benzoic acid → HCID 118130073, compound

HRID 1778131Notes

Reaction equation

HRID 1778131 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[CH:11]=[N:12][CH:13]=[C:14]([CH:19]=2)[C:15]([O:17][CH3:18])=[O:16])[CH:5]=[CH:6][CH:7]=1.[F:20][C:21]([F:32])([F:31])[C:22]1[CH:23]=[C:24]([CH:28]=[CH:29][CH:30]=1)[C:25](O)=[O:26]>>[F:20][C:21]([F:31])([F:32])[C:22]1[CH:23]=[C:24]([CH:28]=[CH:29][CH:30]=1)[C:25]([NH:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[CH:11]=[N:12][CH:13]=[C:14]([CH:19]=2)[C:15]([O:17][CH3:18])=[O:16])[CH:5]=[CH:6][CH:7]=1)=[O:26]

Participants

3

Reactant 2

HCID 99633-(Trifluoromethyl)benzoic acidHCID 118130124HCID 118130124, compound

Product 1

HCID 118130073HCID 118130073, compound

Procedure

In a manner similar to that described in Example 1, methyl 5-((3-aminophenyl)ethynyl)nicotinate and 3-(trifluoromethyl)benzoic acid are converted to the title compound.

Sources & evidence

ORD record
ord-46bf1cec9e444d76bd61cecd5e53ba2a
Source dataset
uspto-grants-2016_02
Patent number
US09266869B2

Reaction notes

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