3-Chloro-4-fluorobenzoic acid → HCID 118130051, compound

HRID 1778132Notes

Reaction equation

HRID 1778132 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[CH:11]=[N:12][CH:13]=[C:14]([CH:19]=2)[C:15]([O:17][CH3:18])=[O:16])[CH:5]=[CH:6][CH:7]=1.[Cl:20][C:21]1[CH:22]=[C:23]([CH:27]=[CH:28][C:29]=1[F:30])[C:24](O)=[O:25]>>[Cl:20][C:21]1[CH:22]=[C:23]([CH:27]=[CH:28][C:29]=1[F:30])[C:24]([NH:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[CH:11]=[N:12][CH:13]=[C:14]([CH:19]=2)[C:15]([O:17][CH3:18])=[O:16])[CH:5]=[CH:6][CH:7]=1)=[O:25]

Participants

3

Reactant 2

HCID 5209893-Chloro-4-fluorobenzoic acidHCID 118130124HCID 118130124, compound

Product 1

HCID 118130051HCID 118130051, compound

Procedure

In a manner similar to that described in Example 1, methyl 5-((3-aminophenyl)ethynyl)nicotinate and 3-chloro-4-fluorobenzoic acid are converted to the title compound.

Sources & evidence

ORD record
ord-133e46035de34c7b91e03d50a06a1906
Source dataset
uspto-grants-2016_02
Patent number
US09266869B2

Reaction notes

Loading…