2-Fluoro-5-methylbenzoic acid → HCID 118130038, compound

HRID 1778133Notes

Reaction equation

HRID 1778133 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[CH:11]=[N:12][CH:13]=[C:14]([CH:19]=2)[C:15]([O:17][CH3:18])=[O:16])[CH:5]=[CH:6][CH:7]=1.[F:20][C:21]1[CH:29]=[CH:28][C:27]([CH3:30])=[CH:26][C:22]=1[C:23](O)=[O:24]>>[F:20][C:21]1[CH:29]=[CH:28][C:27]([CH3:30])=[CH:26][C:22]=1[C:23]([NH:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[CH:11]=[N:12][CH:13]=[C:14]([CH:19]=2)[C:15]([O:17][CH3:18])=[O:16])[CH:5]=[CH:6][CH:7]=1)=[O:24]

Participants

3

Reactant 2

HCID 2428292-Fluoro-5-methylbenzoic acidHCID 118130124HCID 118130124, compound

Product 1

HCID 118130038HCID 118130038, compound

Procedure

In a manner similar to that described in Example 1, methyl 5-((3-aminophenyl)ethynyl)nicotinate and 2-fluoro-5-methylbenzoic acid are converted to the title compound.

Sources & evidence

ORD record
ord-3aec7fd4a5484eca907c07b7e9f39686
Source dataset
uspto-grants-2016_02
Patent number
US09266869B2

Reaction notes

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