m-Toluidine → HCID 118130062, compound

HRID 1778135Notes

Reaction equation

[NH2:1][C:2]1[C:7]([C:8]#[C:9][C:10]2[CH:11]=[C:12]([CH:16]=[CH:17][CH:18]=2)[C:13]([OH:15])=O)=[CH:6][C:5]([C:19]([O:21][CH3:22])=[O:20])=[CH:4][N:3]=1.[NH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([CH3:30])[CH:25]=1>>[NH2:1][C:2]1[C:7]([C:8]#[C:9][C:10]2[CH:18]=[CH:17][CH:16]=[C:12]([C:13](=[O:15])[NH:23][C:24]3[CH:25]=[C:26]([CH3:30])[CH:27]=[CH:28][CH:29]=3)[CH:11]=2)=[CH:6][C:5]([C:19]([O:21][CH3:22])=[O:20])=[CH:4][N:3]=1

Participants

Reactant 2

HCID 7934m-Toluidine

HCID 118130091HCID 118130091, compound

Product 1

HCID 118130062HCID 118130062, compound

Procedure

In a manner similar to that described in Example 1, 3-((2-amino-5-(methoxycarbonyl)pyridin-3-yl)ethynyl)benzoic acid and m-toluidine are converted to the title compound.

Sources & evidence

ORD record: ord-6be46b134739489badc2b55a71f005d2
Source dataset: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09266869B2

Reaction notes

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