HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoro-5-(trifluoromethyl)benzoic acid → Methyl 5-[N-({6-amino-5-[(3-{[2-fluoro-5-(trifluoromethyl)benzoyl]amino}phenyl)ethynyl]pyridin-3-yl}carbonyl)-S-methylsulfonimidoyl]pentanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoro-5-(trifluoromethyl)benzoic acid | HCID 688292 | — |
| Reactant | Methyl 5-[N-({6-amino-5-[(3-aminophenyl)ethynyl]pyridin-3-yl}carbonyl)-S-methylsulfonimidoyl]pentanoate | HCID 118130063 | — |
| Product | Methyl 5-[N-({6-amino-5-[(3-{[2-fluoro-5-(trifluoromethyl)benzoyl]amino}phenyl)ethynyl]pyridin-3-yl}carbonyl)-S-methylsulfonimidoyl]pentanoate | HCID 118130082 | — |
Reaction Steps
In a manner similar to that described in Example 25, methyl 5-[N-({6-amino-5-[(3-aminophenyl)ethynyl]pyridin-3-yl}carbonyl)-S-methylsulfonimidoyl]pentanoate and 2-fluoro-5-(trifluoromethyl)benzoic acid were coupled to give the title compound as a white foam (74 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09266869B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-4b68c62f0a6e48d3ac8a8657352ceae9 |
| Source note | uspto-grants-2016_02 |