6-Amino-5-((3-(3-methylfuran-2-carboxamido)phenyl)ethynyl)nicotinic acid → HCID 118130121, compound

HRID 1778150Notes

Reaction equation

HRID 1778150 reaction equation
[CH3:1][S@@:2]([CH2:5][CH2:6][CH2:7][CH2:8][C:9]([O:11][CH3:12])=[O:10])(=[NH:4])=[O:3].[NH2:13][C:14]1[C:22]([C:23]#[C:24][C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([NH:31][C:32]([C:34]3[O:35][CH:36]=[CH:37][C:38]=3[CH3:39])=[O:33])[CH:26]=2)=[CH:21][C:17]([C:18](O)=[O:19])=[CH:16][N:15]=1>>[NH2:13][C:14]1[N:15]=[CH:16][C:17]([C:18]([N:4]=[S@:2]([CH2:5][CH2:6][CH2:7][CH2:8][C:9]([O:11][CH3:12])=[O:10])([CH3:1])=[O:3])=[O:19])=[CH:21][C:22]=1[C:23]#[C:24][C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([NH:31][C:32]([C:34]2[O:35][CH:36]=[CH:37][C:38]=2[CH3:39])=[O:33])[CH:26]=1

Participants

3

Reactant 2

HCID 576578956-Amino-5-((3-(3-methylfuran-2-carboxamido)phenyl)ethynyl)nicotinic acidHCID 118130075HCID 118130075, compound

Product 1

HCID 118130121HCID 118130121, compound

Procedure

In a manner similar to that described in Example 32, (R)-methyl 5-(S-methylsulfonimidoyl)pentanoate and 6-amino-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinic acid, were reacted to give the title compound.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-064e79caf20f46df882ead9b7612f3a9
Source dataset
uspto-grants-2016_02
Patent number
US09266869B2

Reaction notes

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