Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thiophenol | HCID 7969 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | HCID 131734806 | HCID 131734806 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 118130106 | HCID 118130106 | 92.2% |
Reaction Steps
A mixture of (R)-{[3-(S-methylsulfonimidoyl)propoxy]methyl}benzene nosylate (0.51 g, 1.24 mmol), PhSH (0.22 g, 1.98 mmol) and Cs2CO3 (0.73 g, 2.23 mmol) in CH3CN (10 mL) was stirred at 46° C. overnight, filtered, concentrated, and purified by chromatography (EtOAc/MeOH) to give the title compound (0.26 g, >99% ee).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09266869B2 |
|---|
| Source dataset | uspto-grants-2016_02 |
|---|
| ORD ID | ord-6574e74d1aba42ed8e2d97f8f046c359 |
|---|
| Source note | uspto-grants-2016_02 |
|---|
