HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1778201Generated: October 25, 2026
Trifluoroacetic acid → 5-Benzyl-4-bromo-1-methyl-1H-pyrazole
https://huagongshe.com/reaction/1778201
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Triethylsilane | HCID 12052 | — |
| Reactant | (4-bromo-1-methyl-1H-pyrazol-5-yl)(phenyl)methanol | HCID 14520172 | — |
| Product | 5-Benzyl-4-bromo-1-methyl-1H-pyrazole | HCID 86718547 | — |
Reaction Steps
(4-Bromo-2-methyl-2H-pyrazol-3-yl)-phenyl-methanol (0.50 g; 1.87 mmol) is treated with 3.0 ml TFA and Triethylsilane (1.49 ml; 9.36 mmol) and is heated to 50° C. for 16 hours. The product is purified via reversed phase chromatography under acid conditions.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09266891B2 |
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| Source dataset | uspto-grants-2016_02 |
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| ORD ID | ord-504c76ee750e4f9b862a2eb144fcba8c |
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| Source note | uspto-grants-2016_02 |
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