Phosphorus sulfide (P2S5) → HCID 118324019, compound

HRID 1778279Notes

Reaction equation

HRID 1778279 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=2)[C:9]#[N:10])=[CH:4][CH:3]=1.P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:21]>CCO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=2)[C:9](=[S:21])[NH2:10])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 14817Phosphorus sulfide (P2S5)HCID 3472942-(4-chlorophenyl)-2-(4-nitrophenyl)acetonitrile

Product 1

HCID 118324019HCID 118324019, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2-(4-chlorophenyl)-2-(4-nitrophenyl)acetonitrile (1.000 g, 3.667 mmol, 1 equip) and phosphorus pentasulfide (1.63 g, 7.334 mmol, 2 equip) in EtOH (20 mL) was heated at reflux temperature for 20 h. The reaction mixture was cooled to room temperature and concentrated. The residue was triturated with hot ethyl ether to yield 2-(4-chlorophenyl)-2-(4-nitrophenyl)ethanethioamide as a yellow solid.

Workup

  1. temperatureat reflux temperature for 20 h
  2. concentrationconcentrated
  3. customThe residue was triturated with hot ethyl ether

Sources & evidence

ORD record
ord-ae43d877f3464b75a68c83be2cb5300a
Source dataset
uspto-grants-2016_02
Patent number
US09266835B2

Reaction notes

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