HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1778310Generated: October 30, 2026
2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl → HCID 118324140, compound
https://huagongshe.com/reaction/1778310
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl | HCID 11269872 | — |
| Reactant | B-[(1E)-2-(3-Fluorophenyl)ethenyl]boronic acid | HCID 16217749 | — |
| Reactant | Potassium phosphate, tribasic, monohydrate | HCID 22031701 | — |
| Reactant | HCID 118323959 | HCID 118323959 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 118324140 | HCID 118324140 | — |
Reaction Steps
A mixture of (4-bromo-2-(tert-butoxy)quinolin-6-yl)(4-chlorophenyl)methanone (157 mg, 0.375 mmol), (E)-(3-fluorostyryl)boronic acid (105.8 mg, 0.637 mmol), Pd(OAc)2 (8.42 mg, 0.0375 mmol), SPhos (30.79 mg, 0.0375 mmol), and K3PO4.H2O (159 mg, 0.75 mmol) in anhydrous THF (2.5 mL) was stirred at 30° C. overnight. The reaction was diluted with EtOAc and water. The organics were concentrated and purified by silica column chromatography (20% EtOAc/heptanes) to yield (E)-(2-(tert-butoxy)-4-styrylquinolin-6-yl)(4-chlorophenyl)methanone. (ES, m/z) [M-tBu]+ 404, 405, 407
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09266835B2 |
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| Source dataset | uspto-grants-2016_02 |
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| ORD ID | ord-ceef7cc233dc45e1a1349db0da498a94 |
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| Source note | uspto-grants-2016_02 |
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