Methyl 6-(benzenesulfonylmethyl)-2-hydroxy-3-[2-(2-hydroxyethyl)-furan-3-yl]-benzoate → Methyl 8-(benzenesulfonylmethyl)-4,5-dihydro-3,6-dioxa-benzo[e]azulene-7-carboxylate

HRID 1778340Notes

Reaction equation

HRID 1778340 reaction equation
C(OC(N(C(OC(C)(C)C)=O)C1C(C(OC)=O)=C2C(C3C=COC=3CO2)=CC=1)=O)(C)(C)C.[C:33]1([S:39]([CH2:42][C:43]2[C:48]([C:49]([O:51][CH3:52])=[O:50])=[C:47]([OH:53])[C:46]([C:54]3[CH:58]=[CH:57][O:56][C:55]=3[CH2:59][CH2:60]O)=[CH:45][CH:44]=2)(=[O:41])=[O:40])[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1>>[C:33]1([S:39]([CH2:42][C:43]2[CH:44]=[CH:45][C:46]3[C:54]4[CH:58]=[CH:57][O:56][C:55]=4[CH2:59][CH2:60][O:53][C:47]=3[C:48]=2[C:49]([O:51][CH3:52])=[O:50])(=[O:41])=[O:40])[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1

Participants

3

Reactant 2

HCID 66685569Methyl 6-(benzenesulfonylmethyl)-2-hydroxy-3-[2-(2-hydroxyethyl)-furan-3-yl]-benzoate2×HCID 68093020methyl 7-[bis-(tert-butoxycarbonyl)amino]-4H-furo[2,3-c]-chromene-6-carboxylate

Product 1

HCID 66685884Methyl 8-(benzenesulfonylmethyl)-4,5-dihydro-3,6-dioxa-benzo[e]azulene-7-carboxylate

Procedure

Prepared by proceeding in a similar manner to Intermediate 10, starting from methyl 6-(benzenesulfonylmethyl)-2-hydroxy-3-[2-(2-hydroxyethyl)-furan-3-yl]-benzoate (Intermediate 23).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-c7a5d8f5bff7419283bfad7def9dc63b
Source dataset
uspto-grants-2016_02
Patent number
US09266896B2

Reaction notes

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