Methyl 6-amino-2-hydroxy-3-[2-(2-hydroxyethyl)-furan-3-yl]-benzoate → Methyl 8-amino-4,5-dihydro-3,6-dioxabenzo[e]azulene-7-carboxylate

HRID 1778343Notes

Reaction equation

HRID 1778343 reaction equation
C1(S(CC2C(C(OC)=O)=C3C(C4C=COC=4C(C)O3)=CC=2)(=O)=O)C=CC=CC=1.[NH2:29][C:30]1[C:35]([C:36]([O:38][CH3:39])=[O:37])=[C:34](O)[C:33]([C:41]2[CH:45]=[CH:44][O:43][C:42]=2[CH2:46][CH2:47][OH:48])=[CH:32][CH:31]=1>>[NH2:29][C:30]1[CH:31]=[CH:32][C:33]2[C:41]3[CH:45]=[CH:44][O:43][C:42]=3[CH2:46][CH2:47][O:48][C:34]=2[C:35]=1[C:36]([O:38][CH3:39])=[O:37]

Participants

3

Reactant 2

HCID 66685676Methyl 6-amino-2-hydroxy-3-[2-(2-hydroxyethyl)-furan-3-yl]-benzoate2×HCID 66685680methyl 7-(benzenesulfonylmethyl)-4-methyl-4H-furo[2,3-c]chromene-6-carboxylate

Product 1

HCID 66685816Methyl 8-amino-4,5-dihydro-3,6-dioxabenzo[e]azulene-7-carboxylate

Procedure

Prepared by proceeding in a similar manner to Intermediate 14 starting from methyl 6-amino-2-hydroxy-3-[2-(2-hydroxyethyl)-furan-3-yl]-benzoate (Intermediate 25).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-9475b650a2494dfe8e39ae8f35a771c3
Source dataset
uspto-grants-2016_02
Patent number
US09266896B2

Reaction notes

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