acetic acid (S)-1-((Z)-3-tributylstannanylallyl)-pyrrolidin-3-yl ester → Methyl 7-{4-fluoro-2-[(Z)-3-((S)-3-acetoxypyrrolidin-1-yl)-prop-1-enyl]-benzenesulfonylamino}-4H-furo[2,3-c]chromene-6-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	acetic acid (S)-1-((Z)-3-tributylstannanylallyl)-pyrrolidin-3-yl ester	HCID 66685087	—
Reactant	methyl 7-(2-bromo-4-fluorobenzenesulfonylamino)-4H-furo[2,3-c]chromene-6-carboxylate	HCID 66685486	—
Reactant	methyl 7-{4-fluoro-2-[(Z)-3-((R)-3-acetoxypyrrolidin-1-yl)-prop-1-enyl]-benzenesulfonylamino}-4H-furo[2,3-c]chromene-6-carboxylate	HCID 68093265	—
Product	Methyl 7-{4-fluoro-2-[(Z)-3-((S)-3-acetoxypyrrolidin-1-yl)-prop-1-enyl]-benzenesulfonylamino}-4H-furo[2,3-c]chromene-6-carboxylate	HCID 66685731	—

Reaction Steps

Prepared by proceeding in a similar manner to Intermediate 82, starting from methyl 7-(2-bromo-4-fluorobenzenesulfonylamino)-4H-furo[2,3-c]chromene-6-carboxylate (Intermediate 7) and acetic acid (S)-1-((Z)-3-tributylstannanylallyl)-pyrrolidin-3-yl ester (Intermediate 85).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09266896B2
Source dataset	uspto-grants-2016_02
ORD ID	ord-a70470aac3d04882bf023e17162763e3
Source note	uspto-grants-2016_02