3,4-Difluorobenzaldehyde → HCID 117700306, compound

HRID 1778460Notes

Reaction equation

HRID 1778460 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:6]([C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][C:18]=2Cl)[N:7]=[C:8]([C:12]2[S:13][CH:14]=[CH:15][N:16]=2)[NH:9][C:10]=1[CH3:11])=[O:4].[F:25]C1C=C(C=CC=1F)C=O>>[CH3:1][O:2][C:3]([C:5]1[CH:6]([C:17]2[CH:22]=[CH:21][C:20]([F:23])=[C:19]([F:25])[CH:18]=2)[N:7]=[C:8]([C:12]2[S:13][CH:14]=[CH:15][N:16]=2)[NH:9][C:10]=1[CH3:11])=[O:4]

Participants

3

Reactant 2

HCID 5880883,4-DifluorobenzaldehydeHCID 9820500Methyl 4-(2-Chloro-4-fluorophenyl)-6-methyl-2-(2-thiazolyl)-1,4-dihydropyrimidine-5-carboxylate

Product 1

HCID 117700306HCID 117700306, compound

Procedure

Compound D was prepared in analogy to Compound B with the procedure shown in Scheme 3 by using 3,4-difluoro-benzaldehye instead of 2-chloro-5-fluorobenzaldehyde.

Sources & evidence

ORD record
ord-d245d62f3c734af9934790bd54f68b6a
Source dataset
uspto-grants-2016_02
Patent number
US09266904B2

Reaction notes

Loading…