HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-Methanesulfonyl-3-oxa-7,9-diaza-bicyclo[3.3.1]nonane-9-carboxylic acid benzyl ester → 7-Methanesulfonyl-3-oxa-7,9-diaza-bicyclo[3.3.1]nonane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-Methanesulfonyl-3-oxa-7,9-diaza-bicyclo[3.3.1]nonane-9-carboxylic acid benzyl ester | HCID 117697512 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 7-Methanesulfonyl-3-oxa-7,9-diaza-bicyclo[3.3.1]nonane | HCID 117697889 | 78% |
Reaction Steps
To a solution of the crude Compound Y in MeOH (20 mL) was added 10% Pd on carbon (20 mg). The mixture was stirred under one atmosphere pressure of hydrogen at room temperature. After the reaction was completed, the mixture was filtered and concentrated to give 7-methanesulfonyl-3-oxa-7,9-diaza-bicyclo[3.3.1]nonane (Compound W) (50 mg, 78%) which was directly used for next step. MS: calc'd (MH+) 207, measured (MH+) 207.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09266904B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-e82419ec77e2469db9513c47986dfb8f |
| Source note | uspto-grants-2016_02 |