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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1778485Generated: November 1, 2026

Methyl (R)-6-(bromomethyl)-4-(2-chloro-4-fluorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate → HCID 86294206, compound

https://huagongshe.com/reaction/1778485

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl (R)-6-(bromomethyl)-4-(2-chloro-4-fluorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylateHCID 89995948—
ReactantHCID 117697823HCID 117697823—
ProductHCID 86294206HCID 86294206—

Reaction Steps

The title compound was prepared in analogy to compound 1a in Example 1 starting from compound C and compound 6-fluoro-3-oxa-8-azabicyclo[3.2.1]octane 51a. Preparation of 6-fluoro-3-oxa-8-azabicyclo[3.2.1]octane 51a:

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09266904B2
Source datasetuspto-grants-2016_02
ORD IDord-b40b81dc953b4eaab612653ed7bc6cae
Source noteuspto-grants-2016_02