(Diethylamino)sulfur trifluoride → HCID 117697823, compound

HRID 1778486Notes

Reaction equation

HRID 1778486 reaction equation
O[CH:2]1[CH2:8][CH:7]2[N:9](C(OC(C)(C)C)=O)[CH:3]1[CH2:4][O:5][CH2:6]2.C(N(S(F)(F)[F:23])CC)C.Cl.O1CCOCC1>>[F:23][CH:2]1[CH2:8][CH:7]2[NH:9][CH:3]1[CH2:4][O:5][CH2:6]2

Participants

4

Reactant 3

HCID 123472(Diethylamino)sulfur trifluorideHCID 204431481,4-Dioxane hydrochlorideHCID 67021795HCID 67021795, compound

Product 1

HCID 117697823HCID 117697823, compound

Procedure

Compound 51a was prepared from tert-butyl 6-hydroxy-3-oxa-8-azabicyclo[3.2.1]octane-8-carboxylate G8 by treatment with DAST (diethylaminosulfur trifluoride) followed by HCl/dioxane to remove the N-Boc protection.

Workup

  1. customto remove the N-Boc protection

Sources & evidence

ORD record
ord-6a28111bba1f4a4381e8dcaf5e878f6e
Source dataset
uspto-grants-2016_02
Patent number
US09266904B2

Reaction notes

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