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HRID1778488

反应详情

EQUATION

反应方程式

HRID 1778488 的结构方程式

REACTANTS

反应物

2
结构：C[Si](C)(C)N=C=O
HCID70696

Trimethylsilyl isocyanate

C4H9NOSi

结构：COC(=O)C1=C(CN2C3CNCC2COC3)NC(c2nccs2)=N[C@H]1c1ccc(F)cc1Br
HCID117706699

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)C1=C(CN2C3COCC2CN(C(N)=O)C3)NC(c2nccs2)=N[C@H]1c1ccc(F)cc1Br
HCID117706694

未命名化合物

收率 70.9%

PROCEDURE

实验过程

The title compound was prepared in analogy to Example 18 starting from methyl (4R)-4-(2-bromo-4-fluoro-phenyl)-6-(3-oxa-7,9-diazabicyclo[3.3.1]nonan-9-ylmethyl)-2-thiazol-2-yl-1,4-dihydropyrimidine-5-carboxylate 53b (50 mg, 0.09 mmol) and isocyanato(trimethyl)silane (43 mg, 0.37 mmol). 37 mg of the title compound was isolated as a light yellow powder.