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HRID1778491

反应详情

EQUATION

反应方程式

HRID 1778491 的结构方程式

REACTANTS

反应物

2
结构：O=C(O)CC1CC2COCC1N2
HCID117697829

未命名化合物

结构：COC(=O)C1=C(CBr)NC(c2nccs2)=N[C@H]1c1ccc(F)cc1Br
HCID117706695

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)C1=C(CN2[C@H]3COC[C@@H]2[C@H](CC(=O)O)C3)NC(c2nccs2)=N[C@H]1c1ccc(F)cc1Br
HCID117700220

未命名化合物

收率 24.2%

PROCEDURE

实验过程

The title compound was prepared in analogy to compound 1a in Example 1 starting from methyl (4R)-4-(2-bromo-4-fluoro-phenyl)-6-(bromomethyl)-2-thiazol-2-yl-1,4-dihydropyrimidine-5-carboxylate 53a (73 mg, 0.15 mmol) and 2-(3-oxa-8-azabicyclo[3.2.1]octan-6-yl)acetic acid (121 mg, 0.7 mmol) 64c. 21 mg of the title compound was isolated by preparative HPLC as a yellow powder (yield was 16%).