HCID 117706698, compound → HCID 131734814, compound

HRID 1778494Notes

Reaction equation

HRID 1778494 reaction equation
[NH2:1][CH:2]1[CH2:9][C@@H:8]2[N:10](CC3NC(C4SC=CN=4)=N[C@@H](C4C=CC(F)=CC=4Cl)C=3C(OC)=O)[C@@H:4]([CH2:5][O:6][CH2:7]2)[CH2:3]1.[Br:35][C:36]1[CH:41]=[C:40]([F:42])[CH:39]=[CH:38][C:37]=1[C@H:43]1[C:48]([C:49]([O:51][CH2:52][CH3:53])=[O:50])=[C:47]([CH2:54]Br)[NH:46][C:45]([C:56]2[S:57][CH:58]=[CH:59][N:60]=2)=[N:44]1>>[NH2:1][CH:2]1[CH2:3][C@@H:4]2[N:10]([CH2:54][C:47]3[NH:46][C:45]([C:56]4[S:57][CH:58]=[CH:59][N:60]=4)=[N:44][C@@H:43]([C:37]4[CH:38]=[CH:39][C:40]([F:42])=[CH:41][C:36]=4[Br:35])[C:48]=3[C:49]([O:51][CH2:52][CH3:53])=[O:50])[C@@H:8]([CH2:7][O:6][CH2:5]2)[CH2:9]1

Participants

3

Reactant 2

HCID 117706698HCID 117706698, compoundHCID 118095653HCID 118095653, compound

Product 1

HCID 131734814HCID 131734814, compound

Procedure

Compound 71a was prepared in analogy to 60b in Example 60 by using ethyl (4R)-4-(2-bromo-4-fluoro-phenyl)-6-(bromomethyl)-2-thiazol-2-yl-1,4-dihydropyrimidine-5-carboxylate 70a instead of compound C.

Sources & evidence

ORD record
ord-e679ab54522b484d9a4504da93da4066
Source dataset
uspto-grants-2016_02
Patent number
US09266904B2

Reaction notes

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