HCID 117697539, compound → HCID 117697874, compound

HRID 1778521Notes

Reaction equation

HRID 1778521 reaction equation
C(OC([N:8]1[CH:16]2[CH2:17][O:18][CH2:19][CH:9]1[C:10]1[CH:11]=[N:12][O:13][C:14]=1[CH:15]2[F:20])=O)(C)(C)C>C(O)(C(F)(F)F)=O.C(Cl)Cl>[F:20][CH:15]1[CH:16]2[NH:8][CH:9]([CH2:19][O:18][CH2:17]2)[C:10]2[CH:11]=[N:12][O:13][C:14]1=2

Participants

3

Reactant 1

HCID 117697539HCID 117697539, compound

Product 1

HCID 117697874HCID 117697874, compoundYield 145.1%

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

A solution of 7-Fluoro-5,10-dioxa-4,12-diaza-tricyclo[6.3.1.0*2,6*]dodeca-2(6),3-diene-12-carboxylic acid tert-butyl ester (150 mg) in TFA/DCM (5 mL, 1:2) was stirred at room temperature for 1 h. The solvent was removed in vacuo to give 7-fluoro-5,10-dioxa-4,12-diaza-tricyclo[6.3.1.0*2,6*]dodeca-2(6),3-diene 106a (141 mg) as yellow oil, crude yield: 100%. MS: calc'd (MH+) 185, measured (MH+) 185.

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-d1d5517ac4bd47b1a9f0d3cc8b3f0d19
Source dataset
uspto-grants-2016_02
Patent number
US09266904B2

Reaction notes

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