HCID 117698034, compound → HCID 117697917, compound

Participants

Reaction Steps

Step VIIII: A mixture of compound 116i (340 mg, 1 mmol, 1.0 eq) and Pd(OH)2/C (100 mg, 30%) in MeOH (20 mL) was stirred at room temperature for 16 h under 1 atmosphere of hydrogen. The mixture was filtered, and the filtrate was concentrated to give ethyl 2-(6,6-difluoro-3-hydroxy-8-azabicyclo[3.2.1]octan-3-yl)acetate 116a as a colorless oil, 224 mg, yield: 90%. MS: calc'd (MH+) 250, measured (MH+) 250.

Provenance & Evidence