HCID 117697624, compound → HCID 86293277, compound

HRID 1778546Notes

Reaction equation

HRID 1778546 reaction equation
C(OC([NH:8][C:9]1([C:18]([OH:20])=[O:19])[CH2:16][CH:15]2[NH:17][CH:11]([CH2:12][O:13][CH2:14]2)[CH2:10]1)=O)(C)(C)C.Br[CH2:22][C:23]1[NH:28][C:27]([C:29]2[S:30][CH:31]=[CH:32][N:33]=2)=[N:26][C@@H:25]([C:34]2[CH:39]=[CH:38][CH:37]=[C:36]([F:40])[C:35]=2[F:41])[C:24]=1[C:42]([O:44][CH2:45][CH3:46])=[O:43]>>[NH2:8][C:9]1([C:18]([OH:20])=[O:19])[CH2:10][CH:11]2[N:17]([CH2:22][C:23]3[NH:28][C:27]([C:29]4[S:30][CH:31]=[CH:32][N:33]=4)=[N:26][C@@H:25]([C:34]4[CH:39]=[CH:38][CH:37]=[C:36]([F:40])[C:35]=4[F:41])[C:24]=3[C:42]([O:44][CH2:45][CH3:46])=[O:43])[CH:15]([CH2:14][O:13][CH2:12]2)[CH2:16]1

Participants

3

Reactant 2

HCID 117697624HCID 117697624, compoundHCID 131734829HCID 131734829, compound

Product 1

HCID 86293277HCID 86293277, compoundYield 8.4%

Procedure

The title compound was prepared in analogy to Example 133 by using 7-(tert-butoxycarbonylamino)-3-oxa-9-azabicyclo[3.3.1]nonane-7-carboxylic acid 139a (49 mg) and ethyl (4R)-6-(bromomethyl)-4-(2,3-difluoro-phenyl)-2-thiazol-2-yl-1,4-dihydropyrimidine-5-carboxylate 140a (48 mg). 5 mg of the title compound was isolated.

Workup

  1. customThe title compound was prepared in analogy to Example 133

Sources & evidence

ORD record
ord-d3e336bf10814da79e971846214822af
Source dataset
uspto-grants-2016_02
Patent number
US09266904B2

Reaction notes

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