HCID 117697624, compound → HCID 86293464, compound

HRID 1778548Notes

Reaction equation

HRID 1778548 reaction equation
C(OC([NH:8][C:9]1([C:18]([OH:20])=[O:19])[CH2:16][CH:15]2[NH:17][CH:11]([CH2:12][O:13][CH2:14]2)[CH2:10]1)=O)(C)(C)C.[Br:21][C:22]1[CH:27]=[C:26]([F:28])[CH:25]=[CH:24][C:23]=1[C@H:29]1[C:34]([C:35]([O:37][CH2:38][CH3:39])=[O:36])=[C:33]([CH2:40]Br)[NH:32][C:31]([C:42]2[S:43][CH:44]=[CH:45][N:46]=2)=[N:30]1>>[NH2:8][C:9]1([C:18]([OH:20])=[O:19])[CH2:10][CH:11]2[N:17]([CH2:40][C:33]3[NH:32][C:31]([C:42]4[S:43][CH:44]=[CH:45][N:46]=4)=[N:30][C@@H:29]([C:23]4[CH:24]=[CH:25][C:26]([F:28])=[CH:27][C:22]=4[Br:21])[C:34]=3[C:35]([O:37][CH2:38][CH3:39])=[O:36])[CH:15]([CH2:14][O:13][CH2:12]2)[CH2:16]1

Participants

3

Reactant 2

HCID 117697624HCID 117697624, compoundHCID 118095653HCID 118095653, compound

Product 1

HCID 86293464HCID 86293464, compoundYield 22.6%

Procedure

The title compound was prepared in analogy to Example 133 by using 7-(tert-butoxycarbonylamino)-3-oxa-9-azabicyclo[3.3.1]nonane-7-carboxylic acid 139a (49 mg) and ethyl (4R)-6-(bromomethyl)-4-(2-bromo-4-fluoro-phenyl)-2-thiazol-2-yl-1,4-dihydropyrimidine-5-carboxylate 70a (55 mg). 15 mg of the title compound was isolated.

Workup

  1. customThe title compound was prepared in analogy to Example 133

Sources & evidence

ORD record
ord-d7ed93fe8cc84779861946a503ae005f
Source dataset
uspto-grants-2016_02
Patent number
US09266904B2

Reaction notes

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