HCID 131734835, compound → HCID 117706992, compound

Participants

Reaction Steps

A mixture of O7-benzyl O5-ethyl (5R)-2,2-difluoro-7-azabicyclo[2.2.1]heptane-5,7-dicarboxylate (0.33 g, 1.0 mmol), 10% Pd/C (0.4 g) in methanol (20 mL) was stirred for 24 hours at 1 atm of H2. Removal of catalyst and solvent afforded crude methyl 2,2-difluoro-7-azabicyclo[2.2.1]heptane-5-carboxylate 151a, which was used in next step without purification. Yield: 100%. MS: calc'd (MH +) 192, measured (MH +) 192.

Provenance & Evidence