HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanolamine → 1-Boc-3-[(2-hydroxyethyl)amino]-azetidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | 3-Oxo-azetidine-1-carboxylic acid tert-butyl ester | HCID 1519404 | — |
| Product | 1-Boc-3-[(2-hydroxyethyl)amino]-azetidine | HCID 59284928 | 62.3% |
Reaction Steps
N-Boc-3-azetidinone (1.0 g, 5.84 mmol) was treated with ethanolamine following Procedure 1—Method A to yield N-(N-Boc-azetidin-3-yl)-2-amino-ethanol (0.75 g, 3.46 mmol, 62.3% yield): MS m/e [M+H]+ calcd 217.1, found 217.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09266919B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-d17350beb8194934b51b7157139b3cd8 |
| Source note | uspto-grants-2016_02 |