2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinolin-1(2H)-one → HCID 178493468, compound

HRID 1778663Notes

Reaction equation

HRID 1778663 reaction equation
[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([O:10][CH3:11])=[C:4]([Cl:12])[C:3]=1[C:13]1[N:18]=[C:17]2[NH:19][N:20]=[C:21](I)[C:16]2=[CH:15][N:14]=1.[CH3:23][N:24]1[CH2:33][CH2:32][C:31]2[C:26](=[CH:27][CH:28]=[C:29](B3OC(C)(C)C(C)(C)O3)[CH:30]=2)[C:25]1=[O:43]>>[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([O:10][CH3:11])=[C:4]([Cl:12])[C:3]=1[C:13]1[N:18]=[C:17]2[NH:19][N:20]=[C:21]([C:29]3[CH:30]=[C:31]4[C:26](=[CH:27][CH:28]=3)[C:25](=[O:43])[N:24]([CH3:23])[CH2:33][CH2:32]4)[C:16]2=[CH:15][N:14]=1

Participants

3

Reactant 2

HCID 576129762-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinolin-1(2H)-oneHCID 178493476HCID 178493476, compound

Product 1

HCID 178493468HCID 178493468, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 8, Step 2 starting from 6-(2,6-dichloro-3,5-dimethoxyphenyl)-3-iodo-1H-pyrazolo[3,4-d]pyrimidine and 2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinolin-1(2H)-one. LCMS (M+H)+=484.1/486.0.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-d285072b1ca64ba1a3cace5550e8358b
Source dataset
uspto-grants-2016_02
Patent number
US09266892B2

Reaction notes

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