2-ethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinolin-1(2H)-one → HCID 178462482, compound

HRID 1778665Notes

Reaction equation

HRID 1778665 reaction equation
[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([O:10][CH3:11])=[C:4]([Cl:12])[C:3]=1[C:13]1[N:18]=[C:17]2[NH:19][N:20]=[C:21](I)[C:16]2=[CH:15][N:14]=1.[CH2:23]([N:25]1[CH2:34][CH2:33][C:32]2[C:27](=[CH:28][CH:29]=[C:30](B3OC(C)(C)C(C)(C)O3)[CH:31]=2)[C:26]1=[O:44])[CH3:24]>>[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([O:10][CH3:11])=[C:4]([Cl:12])[C:3]=1[C:13]1[N:18]=[C:17]2[NH:19][N:20]=[C:21]([C:30]3[CH:31]=[C:32]4[C:27](=[CH:28][CH:29]=3)[C:26](=[O:44])[N:25]([CH2:23][CH3:24])[CH2:34][CH2:33]4)[C:16]2=[CH:15][N:14]=1

Participants

3

Reactant 2

HCID 867228122-ethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinolin-1(2H)-oneHCID 178493476HCID 178493476, compound

Product 1

HCID 178462482HCID 178462482, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 8, Step 2 starting from 6-(2,6-dichloro-3,5-dimethoxyphenyl)-3-iodo-1H-pyrazolo[3,4-d]pyrimidine and 2-ethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinolin-1(2H)-one. LCMS (M+H)+=498.1/500.0.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-79cfdffe0580488981eda41c13c07cac
Source dataset
uspto-grants-2016_02
Patent number
US09266892B2

Reaction notes

Loading…