Isopropyl iodide → 2-isopropyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinolin-1(2H)-one

HRID 1778666Notes

Reaction equation

HRID 1778666 reaction equation
[CH3:1][C:2]1([CH3:20])[C:6]([CH3:8])([CH3:7])[O:5][B:4]([C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][CH:18]=2)[C:15](=[O:19])[NH:14][CH2:13][CH2:12]3)[O:3]1.[CH:21](I)([CH3:23])[CH3:22]>>[CH:21]([N:14]1[CH2:13][CH2:12][C:11]2[C:16](=[CH:17][CH:18]=[C:9]([B:4]3[O:3][C:2]([CH3:20])([CH3:1])[C:6]([CH3:7])([CH3:8])[O:5]3)[CH:10]=2)[C:15]1=[O:19])([CH3:23])[CH3:22]

Participants

3

Reactant 2

HCID 6362Isopropyl iodideHCID 219556776-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoquinolin-1-one

Product 1

HCID 867228132-isopropyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinolin-1(2H)-one

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 9, Step 1 starting from 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinolin-1(2H)-one and isopropyl iodide. LCMS (M+H)+=316.1.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-4f1c7cc5413b4e1fa056011cfed30efd
Source dataset
uspto-grants-2016_02
Patent number
US09266892B2

Reaction notes

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